Premium
Forearm bone mineralization in recently diagnosed female adolescents with a premenarchal onset of anorexia nervosa
Author(s) -
Roggen Inge,
Vanbesien Jesse,
Gies Inge,
Van den Eede Ursula,
Lampo Annik,
Louis Olivia,
De Schepper Jean
Publication year - 2016
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.22533
Subject(s) - bone mineral , mineralization (soil science) , quantitative computed tomography , medicine , anorexia nervosa , densitometry , forearm , surgery , osteoporosis , chemistry , eating disorders , organic chemistry , psychiatry , nitrogen
ABSTRACT Objective Data available on bone mineralization by peripheral quantitative computed tomography (pQCT) in adolescents with an early onset anorexia nervosa (AN) is limited. We investigated whether a disturbed bone mineralization can be observed at the distal radius in recently diagnosed female adolescents with AN and a premenarchal onset of this disease. Method Twenty‐four premenarchal patients with AN and 22 healthy females which were age and height matched, were selected from our reference database; both groups underwent a pQCT bone assessment at the distal radius of the nondominant arm. Results The patients age ranged between 13.3 and 18.4 years. Their percent weight loss ranged between 5 and 36% (median 23%) and occurred within the preceding 3 to 44 months. Trabecular volumetric bone mineral density of the patient group was significantly lower than the comparison group (185.6 ± 30.2 vs.209.3 ± 34.0 mm 2 ; p = 0.02). Bone cross‐sectional area, bone mineral content, total volumetric bone mineral density and periosteal circumference were also lower, albeit not significantly. The bone parameters were unrelated to the under nutrition severity and duration. Discussion In premenarchal patients with AN the trabecular bone mineralization of the forearm is significantly reduced, this might be an early indicator of altered bone mineral accrual. © 2016 Wiley Periodicals, Inc.(Int J Eat Disord 2016; 49:809–812)