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The (lack of) effect of alprazolam on eating behavior in anorexia nervosa: A preliminary report
Author(s) -
Steinglass Joanna E.,
Kaplan Simona C.,
Liu Ying,
Wang Yuanjia,
Walsh B. Timothy
Publication year - 2014
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.22343
Subject(s) - alprazolam , anxiety , anorexia nervosa , placebo , psychology , caloric theory , meal , anxiety disorder , benzodiazepine , psychiatry , medicine , eating disorders , alternative medicine , receptor , pathology
Objective Anxiety is a prominent symptom in anorexia nervosa (AN), and higher pre‐meal anxiety has been associated with lower caloric intake. Yet, the causal relationship has not been assessed. We proposed that reducing anxiety with a short acting benzodiazepine would increase caloric intake among individuals with AN. Method In a randomized, double‐blind, placebo controlled cross‐over study, we administered alprazolam 0.75 mg to inpatients with AN ( n = 17) and assessed caloric intake in a laboratory test meal. Within‐subject differences in caloric intake, anxiety, and fatigue were compared between alprazolam and placebo days. Results Caloric intake did not differ on alprazolam versus placebo ( t 15 = 1.72, p = .11). Alprazolam did not reduce anxiety, but was associated with increased fatigue. Discussion This study was not able to evaluate the causal role of anxiety in meal intake among individuals with AN, as alprazolam did not alter anxiety symptoms. These data further suggest that the therapeutic role for short‐acting benzodiazepines in AN is likely limited. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:901–904)