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Volumetric alterations in the nucleus accumbens and caudate nucleus in bulimia nervosa: A structural magnetic resonance imaging study
Author(s) -
Coutinho Joana,
Ramos Ana Filipa,
Maia Liliana,
Castro Liliana,
Conceição Eva,
Geliebter Allan,
Machado Paulo P.P.,
Gonçalves Óscar,
Sampaio Adriana
Publication year - 2015
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.22273
Subject(s) - caudate nucleus , basal ganglia , nucleus accumbens , bulimia nervosa , striatum , psychology , magnetic resonance imaging , ventral striatum , binge eating , psychopathology , neuroscience , functional magnetic resonance imaging , medicine , eating disorders , psychiatry , central nervous system , dopamine , radiology
ABSTRACT Objective Bulimia nervosa (BN) is an eating disorder characterized by recurrent episodes of binge eating and inappropriate compensatory behaviors (such as purging, fasting, or excessive exercise) to prevent weight gain. BN has been associated with deficits in inhibitory control processes. The basal ganglia specifically, the nucleus accumbens (NAc) and the caudate nucleus (CN) are part of the frontostriatal circuits involved in inhibitory control. The main goal of this study was to investigate the presence of morphological alterations in the NAc and the CN in a sample of patients diagnosed with BN. Method Forty‐one female participants, 21 diagnosed with BN and 20 healthy matched controls (HC), underwent a structural magnetic resonance imaging (MRI) acquisition and clinical assessment. The NAc and the CN were manually segmented using the software Slicer 3D. Results The results reveal a significant volumetric decrease in the CN and a preserved NAc volume in BN compared to the control group. Discussion These findings suggest a contributory role of the caudate nucleus part of the dorsal striatum in the psychopathology of BN. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:206–214)