Premium
A pilot study linking reduced fronto–Striatal recruitment during reward processing to persistent bingeing following treatment for binge‐eating disorder
Author(s) -
Balodis Iris M.,
Grilo Carlos M.,
Kober Hedy,
Worhunsky Patrick D.,
White Marney A.,
Stevens Michael C.,
Pearlson Godfrey D.,
Potenza Marc N.
Publication year - 2014
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.22204
Subject(s) - binge eating , binge eating disorder , ventral striatum , psychology , functional magnetic resonance imaging , reward system , prefrontal cortex , neural correlates of consciousness , medial frontal gyrus , neuroscience , audiology , striatum , clinical psychology , bulimia nervosa , eating disorders , medicine , cognition , dopamine
Objective The primary purpose of this study was to examine neurobiological underpinnings of reward processing that may relate to treatment outcome for binge‐eating disorder (BED). Method Prior to starting treatment, 19 obese persons seeking treatment for BED performed a monetary incentive delay task during functional magnetic resonance imaging (fMRI). Analyses examined how the neural correlates of reward processing related to binge‐eating status after 4‐months of treatment. Results Ten individuals continued to report binge‐eating (BE post‐tx ) following treatment and 9 individuals did not (NBE post‐tx ). The groups did not differ in body mass index. The BE post‐tx group relative to the NBE post‐tx group showed diminished recruitment of the ventral striatum and the inferior frontal gyrus during the anticipatory phase of reward processing and reduced activity in the medial prefrontal cortex during the outcome phase of reward processing. Discussion These results link brain reward circuitry to treatment outcome in BED and suggest that specific brain regions underlying reward processing may represent important therapeutic targets in BED. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:376–384)