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Maternal vitamin D levels during pregnancy and offspring eating disorder risk in adolescence
Author(s) -
Allen Karina L.,
Byrne Susan M.,
Kusel Merci M.H.,
Hart Prue H.,
Whitehouse Andrew J.O.
Publication year - 2013
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.22147
Subject(s) - offspring , pregnancy , gestation , body mass index , quartile , vitamin d and neurology , medicine , gestational age , eating disorders , cohort study , psychology , obstetrics , endocrinology , psychiatry , biology , confidence interval , genetics
Objective To determine if maternal vitamin D concentrations at 18 weeks gestation predict offspring eating disorder risk in adolescence. Method Participants were 526 Caucasian mother‐child dyads from the Western Australian Pregnancy Cohort (Raine) Study. The Raine Study has followed participants from 18 weeks gestation to 20 years of age. Maternal serum 25(OH)‐vitamin D concentrations were measured at 18 weeks pregnancy and grouped into quartiles. Offspring eating disorder symptoms were assessed at ages 14, 17 and 20 years. Core analyses were limited to female offspring ( n = 308). Results Maternal 25(OH)‐vitamin D quartiles were a significant predictor of eating disorder risk in female offspring, in multivariate logistic regression models. Vitamin D in the lowest quartile was associated with a 1.8‐fold increase in eating disorder risk relative to concentrations in the highest quartile. This association also accounted for the relationship between offspring season of birth and eating disorder risk. Results were significant after adjusting for sociodemographic characteristics, body mass index and depressive symptoms. Discussion This is the first study to link low gestational vitamin D to increased eating disorder risk in female offspring of Caucasian mothers. Research is needed to extend these findings and to consider how gestational vitamin D may relate to the pathogenesis of eating disorders. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:669–676)