Premium
Striatal dopamine in bulimia nervosa: A pet imaging study
Author(s) -
Broft Allegra,
Shingleton Rebecca,
Kaufman Jenna,
Liu Fei,
Kumar Dileep,
Slifstein Mark,
AbiDargham Anissa,
Schebendach Janet,
Van Heertum Ronald,
Attia Evelyn,
Martinez Diana,
Walsh B. Timothy
Publication year - 2012
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20984
Subject(s) - raclopride , bulimia nervosa , dopamine , putamen , psychology , binge eating , addiction , striatum , eating disorders , medicine , dopamine receptor d2 , cocaine dependence , endocrinology , neuroscience , psychiatry
Objective: Bulimia nervosa (BN) has been characterized as similar to an addiction, though the empirical support for this characterization is limited. This study utilized PET imaging to determine whether abnormalities in brain dopamine (DA) similar to those described in substance use disorders occur in BN. Method: PET imaging with [ 11 C]raclopride, pre/post methylphenidate administration, to assess dopamine type 2 (D 2 ) receptor binding (BP ND ) and striatal DA release (ΔBP ND ). Results: There was a trend toward lower D 2 receptor BP ND in two striatal subregions in the patient group when compared with the control group. DA release in the putamen in the patient group was significantly reduced and, overall, there was a trend toward a difference in striatal DA release. Striatal DA release was significantly associated with the frequency of binge eating. Discussion: These data suggest that BN is characterized by abnormalities in brain DA that resemble, in some ways, those described in addictive disorders. © 2012 by Wiley Periodicals, Inc.