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Respiratory functions in adolescents hospitalized for anorexia nervosa: A prospective study
Author(s) -
Kerem Nogah C.,
Averin Elvira,
Riskin Arieh,
Tov Nave,
Srugo Isaac,
Kugelman Amir
Publication year - 2012
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20960
Subject(s) - medicine , body mass index , prospective cohort study , anorexia nervosa , pulmonary function testing , pulse oximetry , respiratory disease , respiratory rate , cardiology , gastroenterology , pediatrics , anesthesia , heart rate , lung , blood pressure , eating disorders , psychiatry
Objective: To examine the effects of malnourishment on the respiratory system of adolescents with anorexia nervosa (AN) hospitalized for medical stabilization. Method: Prospective study. Study group: hospitalized adolescents with recent onset (<1 year) AN. Control group: adolescents hospitalized for other diagnoses. Excluded: participants with lung disease. Results: Patients' characteristics (mean ± SD) for the AN ( n = 16) and the control group ( n = 13) on admission were: age: 15.0 ± 1.7 vs. 15.2 ± 1.4 years, p = 0.7; body mass index (BMI): 15.5 ± 2.3 vs. 19.8 ± 2.9 kg/m 2 , p < 0.001; venous pH 7.34 ± 0.02 vs. 7.38 ± 0.03, p < 0.001; PCO 2 53.3 ± 4.1 vs. 42.5 ± 3.1 mm Hg, p < 0.001; and HCO 3 28.7 ± 2.0 vs. 25.3 ± 2.4 meq/L, p < 0.001, respectively. Therewere no significant differences in nocturnal respiratory rates, pulse‐oximetry oxygen saturations, or end‐tidal CO 2 . Pulmonary function tests (PFTs) in adolescents with AN revealed no obstructive, restrictive, or significant pulmonary vascular disease except for lower peak expiratory flow rates (PEFRs). During hospitalization (12.3 ± 3.8 days), their weight, BMI, mean nocturnal heart rate, and respiratory rate increased significantly, while their venous PCO 2 and HCO 3 decreased significantly without significant changes in PFTs. Discussion: Adolescents with recent onset AN, admitted for medical stabilization, demonstrate hypercapnia despite normal PFTs, except for decreased PEFRs. These could result from decreased respiratory muscle strength and/or abnormal control of breathing. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)