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Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa
Author(s) -
Duvvuri Vikas,
Cromley Taya,
Klabunde Megan,
Boutelle Kerri,
Kaye Walter H.
Publication year - 2012
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20917
Subject(s) - olanzapine , fluoxetine , anorexia nervosa , psychology , serotonin reuptake inhibitor , atypical antipsychotic , psychiatry , pediatrics , medicine , eating disorders , schizophrenia (object oriented programming) , antipsychotic , serotonin , anxiety , receptor , antidepressant
Abstract Objective: No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison. Method: This report describes a case of 12‐year‐old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy. Results: Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months. Discussion: This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)