Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa | Zendy

Duvvuri Vikas | Zendy; Cromley Taya | Zendy; Klabunde Megan | Zendy; Boutelle Kerri | Zendy; Kaye Walter H. | Zendy

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Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa

Author(s) -

Duvvuri Vikas,

Cromley Taya,

Klabunde Megan,

Boutelle Kerri,

Kaye Walter H.

Publication year - 2012

Publication title -

international journal of eating disorders

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.785

H-Index - 138

eISSN - 1098-108X

pISSN - 0276-3478

DOI - 10.1002/eat.20917

Subject(s) - olanzapine , fluoxetine , anorexia nervosa , psychology , serotonin reuptake inhibitor , atypical antipsychotic , psychiatry , pediatrics , medicine , eating disorders , schizophrenia (object oriented programming) , antipsychotic , serotonin , anxiety , receptor , antidepressant

Objective: No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison. Method: This report describes a case of 12‐year‐old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy. Results: Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months. Discussion: This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa. © 2011 by Wiley Periodicals, Inc. (Int J Eat Disord 2012)

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