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5‐HT 1A receptor binding is increased after recovery from bulimia nervosa compared to control women and is associated with behavioral inhibition in both groups
Author(s) -
Bailer Ursula F.,
Bloss Cinnamon S.,
Frank Guido K.,
Price Julie C.,
Meltzer Carolyn C.,
Mathis Chester A.,
Geyer Mark A.,
Wagner Angela,
Becker Carl R.,
Schork Nicholas J.,
Kaye Walter H.
Publication year - 2011
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20843
Subject(s) - impulsivity , bulimia nervosa , psychology , novelty seeking , sensation seeking , receptor , 5 ht receptor , harm avoidance , depressed mood , impulse control , mood , developmental psychology , medicine , serotonin , neuroscience , clinical psychology , eating disorders , social psychology , temperament , personality
Objective Because altered serotonin (5‐HT) function appears to persist after recovery from bulimia nervosa (RBN), we investigated the 5‐HT 1A receptor, which could contribute to regulation of appetite, mood, impulse control, or the response to antidepressants. Method Thirteen RBN individuals were compared to 21 healthy control women (CW) using positron emission tomography and [carbonyl‐ 11 C]WAY100635 ([ 11 C]WAY). Results RBN had a 23–34% elevation of [ 11 C]WAY binding potential (BP) P in subgenual cingulate, mesial temporal, and parietal regions after adjustments for multiple comparisons. For CW, [ 11 C]WAY BP P was related negatively to novelty seeking, whereas for RBN, [ 11 C]WAY BP P was related positively to harm avoidance and negatively related to sensation seeking. Discussion Alterations of 5‐HT 1A receptor function may provide new insight into efficacy of 5‐HT medication in BN, as well as symptoms such as the ability to inhibit or self‐control the expression of behaviors related to stimulus seeking, aggression, and impulsivity. © 2010 by Wiley Periodicals, Inc. Int J Eat Disord 2011