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Time course of bone loss in patients with anorexia nervosa
Author(s) -
Olmos José M.,
Valero Carmen,
del Barrio Andrés Gómez,
Amado José A.,
Hernández José L.,
MenéndezArango José,
GonzálezMacías Jesús
Publication year - 2010
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20731
Subject(s) - anorexia nervosa , medicine , bone mineral , weight gain , femoral neck , body mass index , weight change , lumbar spine , lumbar , body weight , weight loss , bone density , urology , surgery , osteoporosis , obesity , eating disorders , psychiatry
Objective To evaluate the time course of bone mineral density (BMD) in women with anorexia nervosa (AN) during 2‐year follow‐up. Method We prospectively studied 51 female with AN aged 18–38 years, and 40 age‐matched healthy women (19–34 years). BMD was measured in lumbar spine (LS), femoral neck (FN), and total hip (TH) by DXA. Results At baseline, weight, body mass index, and lumbar and hip BMD were significantly ( p < .001) lower in AN patients than in controls. Patients who gain weight showed a significant increase in BMD at FN (+1.6%; p < .05), and TH (+4.4%; p < .05) and lower nonsignificant changes in LS (+1.3%). Weight at entry, and percent change of weight were significant determinants ( p < .05) of the variability in percent change of BMD at FN and TH, whereas weight at entry was the main determinant of bone modifications at lumbar spine. Discussion Our data emphasize the influence of weight gain in recovery of bone mass in AN patients, especially at the hip. © 2009 by Wiley Periodicals, Inc. Int J Eat Disord 2010; 43:537–542