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The genetics of anorexia nervosa collaborative study: Methods and sample description
Author(s) -
Kaye Walter H.,
Bulik Cynthia M.,
Plotnicov Katherine,
Thornton Laura,
Devlin Bernie,
Fichter Manfred M.,
Treasure Janet,
Kaplan Allan,
Woodside D. Blake,
Johnson Craig L.,
Halmi Katherine,
Brandt Harry A.,
Crawford Steve,
Mitchell James E.,
Strober Michael,
Berrettini Wade,
Jones Ian
Publication year - 2008
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20509
Subject(s) - anorexia nervosa , eating disorders , psychology , context (archaeology) , proband , psychiatry , bulimia nervosa , endophenotype , mental health , clinical psychology , genetics , biology , paleontology , gene , mutation , cognition
Objective: Supported by National Institute of Mental Health (NIMH), this 12‐site international collaboration seeks to identify genetic variants that affect risk for anorexia nervosa (AN). Method: Four hundred families will be ascertained with two or more individuals affected with AN. The assessment battery produces a rich set of phenotypes comprising eating disorder diagnoses and psychological and personality features known to be associated with vulnerability to eating disorders. Results: We report attributes of the first 200 families, comprising 200 probands and 232 affected relatives. Conclusion: These results provide context for the genotyping of the first 200 families by the Center for Inherited Disease Research. We will analyze our first 200 families for linkage, complete recruitment of roughly 400 families, and then perform final linkage analyses on the complete cohort. DNA, genotypes, and phenotypes will form a national eating disorder repository maintained by NIMH and available to qualified investigators. © 2008 by Wiley Periodicals, Inc. Int J Eat Disord 2008