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A history of human‐like dieting alters serotonergic control of feeding and neurochemical balance in a rat model of binge‐eating
Author(s) -
ChandlerLaney Paula C.,
Castañeda Edward,
Viana Jason B.,
Oswald Kimberly D.,
Maldonado Christine R.,
Boggiano Mary M.
Publication year - 2007
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20349
Subject(s) - neurochemical , endocrinology , serotonergic , fluoxetine , serotonin , medicine , dopamine , dieting , binge eating , psychology , monoamine neurotransmitter , mood , eating disorders , psychiatry , weight loss , receptor , obesity
Objective: This study replicated a model of stress‐induced binge‐eating in rats with a history of caloric restriction (HCR), tested their response to SSRI (fluoxetine) treatment, and explored changes in brain monoamine levels. Method: Young female rats with no‐HCR/no‐Stress, no‐HCR/Stress, HCR/no‐Stress, and HCR+Stress (binge‐eating) were treated with fluoxetine. Post‐mortem levels of serotonin, dopamine, and metabolites were assessed from brain regions key to feeding and reward. Results: A 3 mg/kg dose of fluoxetine without effect in the no‐HCR groups suppressed intake of HCR groups, normalizing the binge‐eating of HCR/Stress rats. No differences in monoamines were detected in the hypothalamus or tegmentum but a strong positive relationship between accumbens serotonin and dopamine turnover in no‐HCR rats was absent in rats with HCR. Conclusion: Despite lack of hunger, a history of human‐like dieting alters serotonin function in ways suggesting consequences not only to feeding but also control of reward and mood that are dependent on dopamine/serotonin interactions. © 2006 by Wiley Periodicals, Inc. Int J Eat Disord 2006