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Affect modulates appetite‐related brain activity to images of food
Author(s) -
Killgore William D.S.,
YurgelunTodd Deborah A.
Publication year - 2006
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.20240
Subject(s) - orbitofrontal cortex , affect (linguistics) , appetite , psychology , functional magnetic resonance imaging , calorie , brain mapping , neuroscience , developmental psychology , medicine , cognition , prefrontal cortex , communication
Objective: We examined whether affect ratings predicted regional cerebral responses to high and low‐calorie foods. Method: Thirteen normal‐weight adult women viewed photographs of high and low‐calorie foods while undergoing functional magnetic resonance imaging (fMRI). Regression analysis was used to predict regional activation from positive and negative affect scores. Results: Positive and negative affect had different effects on several important appetite‐related regions depending on the calorie content of the food images. When viewing high‐calorie foods, positive affect was associated with increased activity in satiety‐related regions of the lateral orbitofrontal cortex, but when viewing low‐calorie foods, positive affect was associated with increased activity in hunger‐related regions including the medial orbitofrontal and insular cortex. The opposite pattern of activity was observed for negative affect. Conclusion: These findings suggest a neurobiologic substrate that may be involved in the commonly reported increase in cravings for calorie‐dense foods during heightened negative emotions. © 2006 by Wiley Periodicals, Inc. Int J Eat Disord 2006