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Perception of hunger to insulin‐induced hypoglycemia in anorexia nervosa
Author(s) -
Nakai Yoshikatsu,
Koh Toshikiyo
Publication year - 2001
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.1030
Subject(s) - anorectic , insulin , hypoglycemia , anorexia nervosa , medicine , endocrinology , psychology , saline , pancreatic hormone , anorexia , analysis of variance , body weight , eating disorders , psychiatry , insulin resistance
Objective We studied the effect of insulin‐induced hypoglycemia on changes of hunger ratings in anorectic patients before and after cognitive‐behavioral therapy. Method The subjects were 17 females with restricting anorexia nervosa at low body weight (AN‐R), 6 anorectic patients whose weight was restored after cognitive‐behavioral therapy (AN‐T), and 11 age‐matched female controls. All subjects gave hunger ratings by linear visual analog technique before and after insulin or saline injection. Results Hunger ratings increased significantly 45 min after insulin injection in control females. However, ratings paradoxically decreased after insulin injection in AN‐R females. They increased slightly after insulin injection in AN‐T females, but the difference was not statistically significant. One‐factor analysis of variance for the peak values of hunger ratings was significant. These values in control females were significantly higher than those in AN‐R and AN‐T females. Discussion These results suggest that perception of hunger to insulin‐induced hypoglycemia in AN patients is disturbed. © 2001 by John Wiley & Sons, Inc. Int J Eat Disord 29: 354–357, 2001.