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Topiramate in the treatment of severe bulimia nervosa with comorbid mood disorders: A case series
Author(s) -
Barbee James G.
Publication year - 2003
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.10154
Subject(s) - bulimia nervosa , topiramate , psychiatry , eating disorders , psychology , mood , comorbidity , mood disorders , clinical psychology , psychotherapist , medicine , anxiety , epilepsy
Objective To report observations on the efficacy and tolerability of topiramate in a sample of five patients with severe symptoms of bulimia nervosa and comorbid mood and/or anxiety disorders. Method Topiramate was added to other psychotropic medication under open‐label conditions up to the maximum tolerated dose or until remission of the eating disorder was achieved. Results Topiramate almost completely eliminated binging and purging behavior in three of the five patients. Improvement was maintained throughout the period of follow‐up for up to 18 months. One patient showed a partial, temporary response, and the fifth was intolerant of the drug and unable to complete an adequate trial. Discussion These results suggest strongly that the efficacy of topiramate in patients with bulimia nervosa with and without comorbid mood and anxiety disorders should be investigated more fully. © 2003 by Wiley Periodicals, Inc. Int J Eat Disord 33: 468–472, 2003.