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Brain tissue volume segmentation in patients with anorexia nervosa before and after weight normalization
Author(s) -
Swayze Victor W.,
Andersen Arnold E.,
Andreasen Nancy C.,
Arndt Stephan,
Sato Yutaka,
Ziebell Steve
Publication year - 2003
Publication title -
international journal of eating disorders
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.785
H-Index - 138
eISSN - 1098-108X
pISSN - 0276-3478
DOI - 10.1002/eat.10111
Subject(s) - white matter , medicine , pathophysiology , grey matter , cerebrospinal fluid , endocrinology , anorexia nervosa , psychology , eating disorders , magnetic resonance imaging , psychiatry , radiology
Objective To examine whether gray and white matter volumes are preferentially reduced and cerebral spinal fluid (CSF) increased with starvation in patients with anorexia nervosa compared with healthy controls and to determine what changes occur with weight normalization. Method Whole intracranial volumes of patients and controls were segmented into gray matter, white matter, and CSF volumes and results compared. A subgroup of patients were rescanned after weight normalization. Results Total white matter and several regional white matter volumes were significantly reduced and total and regional CSF volumes were significantly increased in patients versus controls whereas gray matter was not significantly reduced. Total and regional CSF volumes were significantly decreased in patients upon weight normalization whereas white and gray matter volumes increased. Discussion These changes in brain tissue may be related to a variety of pathophysio logic mechanisms. We hypothesize that insulin‐like growth factor‐1 may be involved. © 2002 by Wiley Periodicals, Inc. Int J Eat Disord 33: 33–44, 2003.