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Neural crest delamination and migration: Looking forward to the next 150 years
Author(s) -
Gouignard Nadège,
Andrieu Cyril,
Theveneau Eric
Publication year - 2018
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.23107
Subject(s) - neural crest , biology , mass migration , population , cell migration , evolutionary biology , stem cell , mesenchymal stem cell , neuroscience , history , cognitive science , microbiology and biotechnology , cell , sociology , psychology , genetics , embryo , demography , archaeology , immigration
Summary Neural crest (NC) cells were described for the first time in 1868 by Wilhelm His. Since then, this amazing population of migratory stem cells has been intensively studied. It took a century to fully unravel their incredible abilities to contribute to nearly every organ of the body. Yet, our understanding of the cell and molecular mechanisms controlling their migration is far from complete. In this review, we summarize the current knowledge on epithelial‐mesenchymal transition and collective behavior of NC cells and propose further stops at which the NC train might be calling in the near future.