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Mechano‐sensitive regulation of gene expression during the embryonic development
Author(s) -
Eroshkin Fedor M.,
Zaraisky Andrey G.
Publication year - 2017
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.23026
Subject(s) - biology , morphogenesis , embryogenesis , embryonic stem cell , microbiology and biotechnology , gene expression , mechanosensitive channels , regulation of gene expression , gene , cellular differentiation , embryo , cell fate determination , genetics , transcription factor , receptor , ion channel
Cell movements during embryogenesis produce mechanical tensions that shape the embryo and can also regulate gene expression, thereby affecting cell differentiation. Increasing evidence indicates that mechanosensitive regulation of gene expression plays important roles during embryogenesis by coupling the processes of morphogenesis and differentiation. However, the molecular mechanisms of this phenomenon remain poorly understood. This review focuses on the molecular mechanisms that “translate” mechanical stimuli into gene expression.