Targeted integration of genes in  Xenopus tropicalis | Zendy

Shi Zhaoying | Zendy; Tian Dandan | Zendy; Xin Huhu | Zendy; Lian Jingru | Zendy; Guo Xiaogang | Zendy; Chen Yonglong | Zendy

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Targeted integration of genes in Xenopus tropicalis

Author(s) -

Shi Zhaoying,

Tian Dandan,

Xin Huhu,

Lian Jingru,

Guo Xiaogang,

Chen Yonglong

Publication year - 2017

Publication title -

genesis

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.093

H-Index - 110

eISSN - 1526-968X

pISSN - 1526-954X

DOI - 10.1002/dvg.23006

Subject(s) - xenopus , biology , computational biology , gene , homologous recombination , genetics , homology (biology) , homologous chromosome , gene targeting

With the successful establishment of both targeted gene disruption and integration methods in the true diploid frog Xenopus tropicalis , this excellent vertebrate genetic model now is making a unique contribution to modelling human diseases. Here, we summarize our efforts on establishing homologous recombination‐mediated targeted integration in Xenopus tropicalis , the usefulness, and limitation of targeted integration via the homology‐independent strategy, and future directions on how to further improve targeted gene integration in Xenopus tropicalis .

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