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Using Xenopus to understand human disease and developmental disorders
Author(s) -
Sater Amy K.,
Moody Sally A.
Publication year - 2017
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.22997
Subject(s) - xenopus , biomedicine , biology , computational biology , model organism , systems biology , developmental biology , disease , genome , genomics , african clawed frog , neuroscience , evolutionary biology , bioinformatics , genetics , gene , medicine , pathology
Model animals are crucial to biomedical research. Among the commonly used model animals, the amphibian, Xenopus , has had tremendous impact because of its unique experimental advantages, cost effectiveness, and close evolutionary relationship with mammals as a tetrapod. Over the past 50 years, the use of Xenopus has made possible many fundamental contributions to biomedicine, and it is a cornerstone of research in cell biology, developmental biology, evolutionary biology, immunology, molecular biology, neurobiology, and physiology. The prospects for Xenopus as an experimental system are excellent: Xenopus is uniquely well‐suited for many contemporary approaches used to study fundamental biological and disease mechanisms. Moreover, recent advances in high throughput DNA sequencing, genome editing, proteomics, and pharmacological screening are easily applicable in Xenopus , enabling rapid functional genomics and human disease modeling at a systems level.