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Generation and characterization of mice bearing null alleles of nradd/Nrh2
Author(s) -
Unsain Nicolas,
Dorval Genevieve,
Sheen Jae Hyung,
Barker Philip A
Publication year - 2016
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.22989
Subject(s) - biology , null allele , transmembrane protein , dorsal root ganglion , microbiology and biotechnology , neurotrophin , conditional gene knockout , transmembrane domain , low affinity nerve growth factor receptor , receptor , extracellular , knockout mouse , allele , neuroscience , genetics , gene , phenotype , spinal cord
The Neurotrophin receptor associated death domain gene ( Nradd/Nrh2/Plaidd ) is a type I transmembrane protein with a unique and short N‐terminal extracellular domain and a transmembrane and intracellular domain that bears high similarity to the p75 neurotrophin receptor ( p75NTR/Ngfr ). Initial studies suggested that NRADD regulates neurotrophin signaling but very little is known about its physiological roles. We have generated and characterized NRADD conditional and germ‐line null mouse lines. These mice are viable and fertile and dońt show evident abnormalities. However, NRADD deletion results in an increase in the proportion of dorsal root ganglion neurons expressing p75NTR. The NRADD conditional and complete knockout mouse lines generated are new and useful tools to study the physiological roles of NRADD. Birth Defects Research (Part A) 106:605–612, 2016. © 2016 Wiley Periodicals, Inc.