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Broad‐complex, tramtrack, and bric‐à‐brac (BTB) proteins: Critical regulators of development
Author(s) -
Chaharbakhshi Edwin,
Jemc Jennifer C.
Publication year - 2016
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.22964
Subject(s) - zinc finger , biology , chromatin , gene , microbiology and biotechnology , genetics , chromatin remodeling , transcriptional regulation , dna binding protein , protein domain , transcription factor
Broad‐complex, Tramtrack, and Bric‐à‐brac/poxvirus and zinc finger (BTB/POZ) family proteins are a diverse family of proteins that are characterized by the presence of a common protein‐protein interaction domain, known as the BTB domain. BTB proteins have been identified in poxviruses and many eukaryotes, and have diverse functions, ranging from transcriptional regulation and chromatin remodeling to protein degradation and cytoskeletal regulation. Specificity of function is determined in part by additional domains present in BTB family proteins, as well as by interaction partners. Studies of BTB proteins in Drosophila and mammalian systems have revealed the importance of these genes in multiple developmental contexts, as well as in cancer and neurological and musculoskeletal diseases. In this review, we discuss the functions of BTB/POZ proteins during development with an emphasis on BTB‐zinc finger (BTB‐ZF) proteins, which play critical roles in transcriptional regulation and chromatin remodeling.