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Follow your gut: Relaying information from the site of left–right symmetry breaking in the mouse
Author(s) -
Saijoh Yukio,
Viotti Manuel,
Hadjantonakis AnnaKaterina
Publication year - 2014
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.22783
Subject(s) - asymmetry , relay , endoderm , biology , nodal , morphogenesis , signal (programming language) , symmetry (geometry) , node (physics) , symmetry breaking , anatomy , physics , microbiology and biotechnology , computer science , genetics , embryonic stem cell , geometry , gene , mathematics , acoustics , power (physics) , quantum mechanics , programming language
Summary A central unresolved question in the molecular cascade that drives establishment of left–right (LR) asymmetry in vertebrates are the mechanisms deployed to relay information between the midline site of symmetry‐breaking and the tissues which will execute a program of asymmetric morphogenesis. The cells located between these two distant locations must provide the medium for signal relay. Of these, the gut endoderm is an attractive candidate tissue for signal transmission since it comprises the epithelium that lies between the node, where asymmetry originates, and the lateral plate, where asymmetry can first be detected. Here, focusing on the mouse as a model, we review our current understanding and entertain open questions concerning the relay of LR information from its origin. genesis 52:503–514, 2014. © 2014 Wiley Periodicals, Inc.