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Every which way—nanos gene regulation in echinoderms
Author(s) -
Oulhen Nathalie,
Wessel Gary M.
Publication year - 2014
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.22737
Subject(s) - biology , gene , developmental biology , transcription (linguistics) , gene expression , regulation of gene expression , transcription factor , evolutionary biology , microbiology and biotechnology , genetics , linguistics , philosophy
Summary Nanos is an essential factor of germ line success in all animals tested. This gene encodes a Zn‐finger RNA‐binding protein that in complex with its partner pumilio binds to and changes the fate of several known transcripts. We summarize here the documented functions of Nanos in several key organisms, and then emphasize echinoderms as a working model for how nanos expression is regulated. Nanos presence outside of the target cells is often detrimental to the animal, and in sea urchins, nanos expression appears to be regulated at every step of transcription, and post‐transcriptional activity, making this gene product exciting, every which way. genesis 52:279–286. © 2013 Wiley Periodicals, Inc.