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Drosophila LSD1‐CoREST demethylase complex regulates DPP/TGFβ signaling during wing development
Author(s) -
Curtis Brenda J.,
Zraly Claudia B.,
Dingwall Andrew K.
Publication year - 2013
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.22346
Subject(s) - biology , microbiology and biotechnology , demethylase , histone , epigenetics , transcription factor , chromatin , chromatin remodeling , histone methyltransferase , reprogramming , gene , genetics
The choice and timing of specific developmental pathways in organogenesis are determined by tissue‐specific temporal and spatial cues that are acted upon to impart unique cellular and compartmental identities. A consequence of cellular signaling is the rapid transcriptional reprogramming of a wide variety of target genes. To overcome intrinsic epigenetic chromatin barriers to transcription modulation, histone modifying and remodeling complexes are employed. The deposition or erasure of specific covalent histone modifications, including acetylation, methylation, and ubiquitination are essential features of gene activation and repression. We have found that the activity of a specific class of histone demethylation enzymes is required for the specification of vein cell fates during Drosophila wing development. Genetic tests revealed that the Drosophila LSD1‐CoREST complex is required for proper cell specification through regulation of the DPP/TGFβ pathway. An important finding from this analysis is that LSD1‐CoREST functions through control of rhomboid expression in an EGFR‐independent pathway. genesis51:16–31, 2013. © 2012 Wiley Periodicals, Inc.