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Zebrafish Tshz3b negatively regulates hox function in the developing hindbrain
Author(s) -
Erickson Timothy,
Pillay Laura M.,
Waskiewicz Andrew J.
Publication year - 2011
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20805
Subject(s) - hindbrain , zebrafish , green fluorescent protein , microbiology and biotechnology , hox gene , rhombomere , biology , neuroscience , neurofilament , embryo , confocal , alcam , anatomy , immunohistochemistry , gene expression , gene , immunology , genetics , physics , cell adhesion molecule , optics
Confocal images of hindbrain neurons in two‐day old wild type (left) and tshz3b mRNA‐injected (right) zebrafish embryos. The two top panels show the GFP‐positive branchiomotor neurons (green) of Tg(isl1:GFP) embryos co‐stained with the zn‐5 antibody against Alcam a (red). The bottom two panels highlight the hindbrain reticulospinal neurons as visualized using the rmo44 α‐Neurofilament‐medium antibody. Overexpression of tshz3b perturbs the normal segmental patterning of these neurons.