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Podosomal proteins as causes of human syndromes: A role in craniofacial development?
Author(s) -
CejudoMartin Pilar,
Courtneidge Sara A.
Publication year - 2011
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20732
Subject(s) - podosome , invadopodia , microbiology and biotechnology , biology , extracellular matrix , craniofacial , morphogenesis , actin , cancer cell , cell , cancer , cytoskeleton , genetics , gene
Podosomes and invadopodia are actin‐rich protrusions of the plasma membrane important for matrix degradation and cell migration. Most of the information in this field has been obtained in cancer cells, where the presence of invadopodia has been related to increased invasiveness and metastatic potential. The importance of the related podosome structure in other pathological or physiological processes that require cell invasion is relatively unexplored. Recent evidence indicates that essential components of podosomes are responsible for several human syndromes, some of which are characterized by serious developmental defects involving the craniofacial area, skeleton and heart, and very poor prognosis. Here we will review them and discuss the possible role of podosomes as a player in correct embryo development. genesis 49:209–221, 2011. © 2011 Wiley‐Liss, Inc.