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A novel null allele of mouse Dscam survives to adulthood on an inbred C3H background with reduced phenotypic variability
Author(s) -
Fuerst Peter G.,
Harris Belinda S.,
Johnson Kenneth R.,
Burgess Robert W.
Publication year - 2010
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20681
Subject(s) - biology , retina , null allele , allele , mutant , phenotype , inbred strain , retinal , stain , microbiology and biotechnology , genetics , gene , neuroscience , staining , biochemistry
Rod bipolar cells (green; PKCa+), a subset of retinal bipolar cells (red; CHX10+) span the two synaptic layers of the mouse retina, Nuclei in the three nuclear layers of the mouse retina are blue (Hoechst stain). A new mutant mouse allele of Down syndrome cell adhesion molecule ( Dscam ) was used to study the role of this gene in synaptic lamination of the mouse retina. See the article by Fuerst et al. in this issue.