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Gonadal sex differentiation and expression of Sox9a2 , Dmrt1 , and Foxl2 in Oryzias luzonensis
Author(s) -
Nakamoto Masatoshi,
Muramatsu Shinsuke,
Yoshida Shoko,
Matsuda Masaru,
Nagahama Yoshitaka,
Shibata Naoki
Publication year - 2009
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20498
Subject(s) - oryzias , sexual differentiation , biology , testis determining factor , development of the gonads , gene , sex reversal , disorders of sex development , andrology , gonad , genetics , endocrinology , y chromosome , medicine
Oryzias luzonensis is closely related to the medaka, O. latipes . The sex of both species is determined by an XX‐XY system. However, the testis determining gene ( DMY/Dmrt1bY ) found in O. latipes does not exist in O. luzonensis . Instead, a different gene is thought to act as a testis determining gene. In this study, we focused the gonadal sex differentiation process in O. luzonensis under different testis determining gene. First, we observed the gonadal development of O. luzonensis histologically. We then analyzed the expression of Sox9a2/Sox9b , Dmrt1 , and Foxl2 during early development. Our results suggest that the sexual differentiation of germ cells in O. luzonensis is initiated later than in O. latipes . However, the timing of the sexual differentiation of the supporting cell linage is similar between the species. genesis 47:289–299, 2009. © 2009 Wiley‐Liss, Inc.