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De Novo DNA methylation independent establishment of maternal imprint on X chromosome in mouse oocytes
Author(s) -
Chiba Hatsune,
Hirasawa Ryutaro,
Kaneda Masahiro,
Amakawa Yuko,
Li En,
Sado Takashi,
Sasaki Hiroyuki
Publication year - 2008
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20496
Subject(s) - biology , blastocyst , embryo , histone , methyltransferase , dosage compensation , chromosome , dna , genetics , microbiology and biotechnology , dna methylation , x inactivation , histone methyltransferase , x chromosome , methylation , gene , embryogenesis , gene expression
Abstract Mouse blastocyst stage embryo stained for histone H3 lysine‐27 trimethylation (red) and DNA (blue). H3K27me3 marks the inactive X chromosome. The study by Chiba et al. in this issue suggests that de novo DNA methyltransferases are dispensable for setting the imprint on the maternally‐derived X chromsome in growing oocytes. See Chiba et al. in this issue.

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