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Sfrp1, Sfrp2, and Sfrp5 regulate the Wnt/β‐catenin and the planar cell polarity pathways during early trunk formation in mouse
Author(s) -
Satoh Wataru,
Matsuyama Makoto,
Takemura Hiromasa,
Aizawa Shinichi,
Shimono Akihiko
Publication year - 2008
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20489
Subject(s) - frizzled , wnt signaling pathway , neural tube , biology , mutant , polarity (international relations) , microbiology and biotechnology , cell polarity , in situ hybridization , gene , signal transduction , genetics , cell , embryo , messenger rna
The secreted frizzled‐related protein gene family encodes proteins that regulate Wnt signaling. Msx1 in situ hybridization of 9.5 days post coitus mouse embryos showing normal neural tube development in an Sfrp1; Sfrp2 double mutant (left) but severe neural tube defects in a Looptail ( Lp /+); Sfrp1; Sfrp2 triple mutant (right). These findings suggest that Sfrps regulate the Wnt planar cell polarity pathway. See Satoh et al . in this issue.