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Gasdermin D ( Gsdmd ) is dispensable for mouse intestinal epithelium development
Author(s) -
Fujii Tomoaki,
Tamura Masaru,
Tanaka Shigekazu,
Kato Yoriko,
Yamamoto Hiromi,
Mizushina Youichi,
Shiroishi Toshihiko
Publication year - 2008
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20412
Subject(s) - intestinal epithelium , subfamily , biology , mutant , gastrointestinal tract , epithelium , phenotype , microbiology and biotechnology , gene , genetics , biochemistry
Members of the novel gene family Gasdermin ( Gsdm ) are exclusively expressed in a highly tissue‐specific manner in the epithelium of skin and the gastrointestinal tract. Based on their expression patterns and the phenotype of the Gsdma3 spontaneous mutations, it is inferred that the Gsdm family genes are involved in epithelial cell growth and/or differentiations in different tissues. To investigate possible roles of the Gsdm gene family in the development of intestinal tracts, we generated a Gsdmd mutant mouse, which is a solitary member of the Gsdmd subfamily and which is predominantly expressed in the intestinal tract by means of targeted disruption. In the mutant homozygotes, we found no abnormality of intestinal tract morphology. Moreover, in mutant mice, there was normal differentiation of all constituent cell types of the intestinal epithelium. Thus, this study clearly shows that Gsdmd is not essential for development of mouse intestinal tract or epithelial cell differentiation. genesis 46:418–423, 2008. © 2008 Wiley‐Liss, Inc.