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Notch and suppressor of Hairless regulate levels but not patterns of Delta expression in Drosophila
Author(s) -
Parks Annette L.,
Shalaby Nevine A.,
Muskavitch Marc A.T.
Publication year - 2008
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20391
Subject(s) - hairless , notch signaling pathway , biology , delta , context (archaeology) , hes3 signaling axis , microbiology and biotechnology , signal transduction , genetics , physics , paleontology , astronomy
The Notch signal transduction pathway is highly conserved and governs many developmental decisions in metazoans. The ligand Delta, and its receptor Notch, are often expressed in complementary patterns during Drosophila postembryonic development. Notch signaling is thought to play a role in generation of these complementary patterns through feedback mechanisms that regulate Delta and Notch expression. We have examined Delta expression during postembryonic development, following global alteration of Notch‐dependent or Su(H)‐dependent transcriptional regulation. We find that Notch and Su(H) regulate Delta expression in a manner that varies by context. Surprisingly, we find that wild type Delta expression levels are influenced by Su(H)‐dependent mechanisms only in regions of high Delta/low Notch expression. In contrast, Delta expression levels in regions of low Delta/high Notch expression appear to be unaffected by Su(H)‐mediated regulation. We conclude that Notch pathway feedback regulation is unlikely to contribute to the generation of complementary patterns in the contexts examined. genesis 46:265–275, 2008. © 2008 Wiley‐Liss, Inc.