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Three loci on mouse chromosome 5 and 10 modulate sex determination in XX Ods /+ mice
Author(s) -
Poirier Christophe,
Moran Jennifer L.,
Kovanci Ertug,
Petit Deborah C.,
Beier David R.,
Bishop Colin E.
Publication year - 2007
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20312
Subject(s) - testis determining factor , biology , genetics , allele , sox9 , y chromosome , gene , chromosome , lineage (genetic) , microbiology and biotechnology , gene expression
In mouse, XY embryos are committed to the male sex determination pathway after the transient expression of the Y‐linked Sry gene in the Sertoli cell lineage between 10.5 and 12.5 dpc. In the C57BL/6J strain, male sex determination program can be modulated by some autosomal genes. The C57BL/6J alleles at these autosomal loci can antagonize male sex determination in combination with specific Sry alleles. In this report, the authors have identified an effect of these C57BL/6J specific alleles in combination with a mutated Sox9 allele, Sox9 Ods . Authors report the mapping of three of these genetic loci on mouse chromosome 5 and 10 in a backcross of the Ods mutation to the C57BL/6J background. Our study confirms the importance of the strain C57BL/6J for the investigation of the genetic mechanisms that control sex determination. genesis 45:452–455, 2007. Published 2007 Wiley‐Liss, Inc.