Premium
Fat‐body remodeling in Drosophila melanogaster
Author(s) -
Nelliot Archana,
Bond Nichole,
Hoshizaki Deborah K.
Publication year - 2006
Publication title -
genesis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.093
H-Index - 110
eISSN - 1526-968X
pISSN - 1526-954X
DOI - 10.1002/dvg.20229
Subject(s) - drosophila melanogaster , metamorphosis , biology , melanogaster , microbiology and biotechnology , fat body , adipose tissue , anatomy , endocrinology , larva , gene , genetics , botany
The remodeling of the larval fat body is observed in many insects during metamorphosis, but little is known about the physiological importance or the regulation of this process. In Drosophila melanogaster , fat‐body remodeling involves the dissociation of the fat body into individual fat cells, which persist throughout pupal development but are later removed by cell death in the young adult. Inhibition of fat‐body dissociation is associated with pharate adult lethality and thus is likely to be an essential developmental event. As a start toward understanding the role of fat‐body remodeling in the life history of insects, we carried out a detailed study of fat‐body disassociation in D. melanogaster using fluorescent microscopy, and tested whether this process is mediated by hemocytes as proposed for fat‐body remodeling in Sarcophaga peregrina . We identified and correlated stereotypic events in fat‐body dissociation with developmental changes during metamorphosis, and have demonstrated by cell ablation studies that fat‐body remodeling in D. melanogaster is a hemocyte independent process. genesis 44:396–400, 2006. Published 2006 Wiley‐Liss, Inc.