Premium
Atavisms in the avian hindlimb and early developmental polarity of the limb
Author(s) -
Bonatto Paese Christian L.,
Hawkins Michael Brent,
Brugmann Samantha A.,
Harris Matthew P.
Publication year - 2021
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.318
Subject(s) - biology , hindlimb , polarity (international relations) , limb development , anatomy , microbiology and biotechnology , genetics , embryo , cell
Background The naturally occurring chicken mutant talpid 2 ( ta 2 ), best known for its limb and craniofacial defects, has long served as a valuable tool for developmental biologists studying growth and patterning of craniofacial structures and the limb. The mutant provides a unique tool to examine the molecular and cellular processes regulating limb development. Results This mutant also provides unique insights into the evolution of developmental genetic programs. Previous work defined the appearance of atavistic dentition in ta 2 embryos. Herein we describe the appearance of ancestral characters of the hindlimb in embryonic ta 2 chicken embryos. Conclusion As the ta 2 phenotype arises as a result of mutation in C2CD3 and disrupted cilia function, this mutant provides genetic and developmental insight into the causes of asymmetry in the limb and also a model for the evolution of the avian hindlimb.