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Hippo‐yap signaling in ocular development and disease
Author(s) -
Lee Matthew,
Goraya Navneet,
Kim Seonhee,
Cho SeoHee
Publication year - 2018
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24628
Subject(s) - biology , hippo signaling pathway , microbiology and biotechnology , cell growth , cell fate determination , organogenesis , signal transduction , cell polarity , cell , stem cell , homeostasis , transcription factor , genetics , gene
The Hippo‐Yes associated protein (Yap) pathway plays an important role in organ size control by regulating cell proliferation, apoptosis, and stem cell renewal. Hippo‐Yap signaling also functions at the level of cellular development in a variety of organs through its effects on cell cycle control, cell survival, cell polarity, and cell fate. Because of its important roles in normal development and homeostasis, abnormal regulation of this pathway has been shown to lead to pathological outcomes such as tissue overgrowth, tumor formation, and abnormal organogenesis, including ocular‐specific disorders. In this review, we summarize how normal and perturbed control of Yap signaling is implicated in ocular development and disease Developmental Dynamics 247:794–806, 2018 . © 2018 Wiley Periodicals, Inc.