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Maternal immune activation in neurodevelopmental disorders
Author(s) -
Solek Cynthia M.,
Farooqi Nasr,
Verly Myriam,
Lim Tony K.,
Ruthazer Edward S.
Publication year - 2018
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24612
Subject(s) - neurodevelopmental disorder , autism , schizophrenia (object oriented programming) , immune system , autism spectrum disorder , biology , neuroscience , immunology , psychiatry , psychology
Converging lines of evidence from basic science and clinical studies suggest a relationship between maternal immune activation (MIA) and neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia. The mechanisms through which MIA increases the risk of neurodevelopmental disorders have become a subject of intensive research. This review aims to describe how dysregulation of microglial function and immune mechanisms may link MIA and neurodevelopmental pathologies. We also summarize the current evidence in animal models of MIA. Developmental Dynamics 247:588–619, 2018 . © 2017 Wiley Periodicals, Inc.