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MRTFs‐ master regulators of EMT
Author(s) -
Gasparics Ákos,
Sebe Attila
Publication year - 2018
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24544
Subject(s) - biology , transcription factor , microbiology and biotechnology , epithelial–mesenchymal transition , myofibroblast , transcription (linguistics) , fibrosis , cancer , genetics , metastasis , gene , medicine , linguistics , philosophy
Recent evidence implicates the myocardin‐related transcription factors (MRTFs) as key mediators of the phenotypic plasticity leading to the conversion of various cell types into myofibroblasts. This review highlights the function of MRTFs during development, fibrosis and cancer, and the role of MRTFs during epithelial–mesenchymal transitions (EMTs) underlying these processes. EMT is a sequentially orchestrated process where cells undergo a rearrangement of their cell contacts and activate a fibrogenic and myogenic expression program. MRTFs interact with and regulate the major signaling pathways and the expression of key markers and transcription factors involved in EMT. These functions indicate a central role for MRTFs in controlling the process of EMT. Developmental Dynamics 247:396–404, 2018 . © 2017 Wiley Periodicals, Inc.