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Mitochondrial dynamics in the regulation of neurogenesis: From development to the adult brain
Author(s) -
Khacho Mireille,
Slack Ruth S.
Publication year - 2018
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24538
Subject(s) - neurogenesis , biology , mitochondrion , neural stem cell , neuroscience , organelle , cell fate determination , mammalian brain , microbiology and biotechnology , dynamics (music) , stem cell , genetics , psychology , gene , pedagogy , transcription factor
Mitochondria are classically known to be the cellular energy producers, but a renewed appreciation for these organelles has developed with the accumulating discoveries of additional functions. The importance of mitochondria within the brain has been long known, particularly given the high‐energy demanding nature of neurons. The energy demands imposed by neurons require the well‐orchestrated morphological adaptation and distribution of mitochondria. Recent studies now reveal the importance of mitochondrial dynamics not only in mature neurons but also during neural development, particularly during the process of neurogenesis and neural stem cell fate decisions. In this review, we will highlight the recent findings that illustrate the importance of mitochondrial dynamics in neurodevelopment and neural stem cell function. Developmental Dynamics 247:47–53, 2018 . © 2017 Wiley Periodicals, Inc.