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ETS transcription factor ETV2/ER71/Etsrp in hematopoietic and vascular development, injury, and regeneration
Author(s) -
Zhao Haiyong,
Xu Canxin,
Lee TaeJin,
Liu Fang,
Choi Kyunghee
Publication year - 2017
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24483
Subject(s) - regeneration (biology) , biology , haematopoiesis , transcription factor , microbiology and biotechnology , regenerative medicine , hematopoietic stem cell , stem cell , vascular endothelial growth factor , vascular endothelial growth factor b , immunology , vascular endothelial growth factor a , cancer research , vegf receptors , genetics , gene
The major goal in regenerative medicine is to repair and restore injured, diseased or aged tissue function, thereby promoting general health. As such, the field of regenerative medicine has great translational potential in undertaking many of the health concerns and needs that we currently face. In particular, hematopoietic and vascular systems supply oxygen and nutrients and thus play critical roles in tissue development and tissue regeneration. Additionally, tissue vasculature serves as a tissue stem cell niche and thus contributes to tissue homeostasis. Notably, hematopoietic and vascular systems are sensitive to injury and subject to regeneration. As such, successful hematopoietic and vascular regeneration is prerequisite for efficient tissue repair and organismal survival and health. Recent studies have established that the interplay among the ETS transcription factor ETV2, vascular endothelial growth factor, and its receptor VEGFR2/FLK1 is essential for hematopoietic and vascular development. Emerging studies also support the role of these three factors and possible interplay in hematopoietic and vascular regeneration. Comprehensive understanding of the molecular mechanisms involved in the regulation and function of these three factors may lead to more effective approaches in promoting tissue repair and regeneration. Developmental Dynamics 246:318–327, 2017 . © 2016 Wiley Periodicals, Inc.