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Morphoregulatory pathways in prostate ductal development
Author(s) -
Montano Monica,
Bushman Wade
Publication year - 2017
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24478
Subject(s) - biology , prostate , prostate cancer , extracellular matrix , prostate diseases , neuroscience , bioinformatics , cancer , microbiology and biotechnology , genetics
The mouse prostate is a male sex‐accessory gland comprised of a branched ductal network arranged into three separate bilateral lobes: the anterior, dorsolateral, and ventral lobes. Prostate ductal development is the primary morphogenetic event in prostate development and requires a complex regulation of spatiotemporal factors. This review provides an overview of prostate development and the major genetic regulators and signaling pathways involved. To identify new areas for further study, we briefly highlight the likely important, but relatively understudied, role of the extracellular matrix (ECM). Finally, we point out the potential importance of the ECM in influencing the behavior and prognosis of prostate cancer. Developmental Dynamics 246:89–99, 2017 . © 2016 Wiley Periodicals, Inc.