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Nonneuronal roles for the reelin signaling pathway
Author(s) -
Khialeeva Elvira,
Carpenter Ellen M.
Publication year - 2017
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24462
Subject(s) - reelin , dab1 , biology , low density lipoprotein receptor related protein 8 , microbiology and biotechnology , signal transduction , neuroscience , signal transducing adaptor protein , receptor , extracellular matrix , genetics , endocrinology , lipoprotein , very low density lipoprotein , cholesterol
The reelin signaling pathway has been established as an important regulator of cell migration during development of the central nervous system, and disruptions in reelin signaling alter the positioning of many types of neurons. Reelin is a large extracellular matrix glycoprotein and governs cell migration through activation of multiple intracellular signaling events by means of the receptors ApoE receptor 2 (ApoER2) and very low density lipoprotein receptor (VLDLR), and the intracellular adaptor protein Disabled‐1 (Dab1). Earlier studies reported expression of reelin in nonneuronal tissues, but the functions of this signaling pathway outside of the nervous system have not been studied until recently. A large body of evidence now suggests that reelin functions during development and disease of multiple nonneuronal tissues. This review addresses recent advances in the field of nonneuronal reelin signaling. Developmental Dynamics 246:217–226, 2017 . © 2016 Wiley Periodicals, Inc.