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Navigating the labyrinth of cardiac regeneration
Author(s) -
Lambers Erin,
Kume Tsutomu
Publication year - 2016
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24397
Subject(s) - biology , regeneration (biology) , disease , heart disease , myocardial infarction , stem cell , regenerative medicine , heart development , intensive care medicine , neuroscience , bioinformatics , microbiology and biotechnology , medicine , genetics , embryonic stem cell , gene
Heart disease is the number one cause of morbidity and mortality in the world and is a major health and economic burden, costing the United States Health Care System more than $200 billion annually. A major cause of heart disease is the massive loss or dysfunction of cardiomyocytes caused by myocardial infarctions and hypertension. Due to the limited regenerative capacity of the heart, much research has focused on better understanding the process of differentiation toward cardiomyocytes. This review will highlight what is currently known about cardiac cell specification during mammalian development, areas of controversy, cellular sources of cardiomyocytes, and current and potential uses of stem cell derived cardiomyocytes for cardiac therapies. Developmental Dynamics 245:751–761, 2016 . © 2016 Wiley Periodicals, Inc.