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LRP2, an auxiliary receptor that controls sonic hedgehog signaling in development and disease
Author(s) -
Christ Annabel,
Herzog Katja,
Willnow Thomas E.
Publication year - 2016
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24394
Subject(s) - morphogen , patched , biology , hedgehog , smoothened , sonic hedgehog , hedgehog signaling pathway , context (archaeology) , progenitor cell , microbiology and biotechnology , receptor , signal transduction , stem cell , neuroscience , genetics , paleontology , gene
To fulfill their multiple roles in organ development and adult tissue homeostasis, hedgehog (HH) morphogens act through their receptor Patched (PTCH) on target cells. However, HH actions also require HH binding proteins, auxiliary cell surface receptors that agonize or antagonize morphogen signaling in a context‐dependent manner. Here, we discuss recent findings on the LDL receptor‐related protein 2 (LRP2), an exemplary HH binding protein that modulates sonic hedgehog activities in stem and progenitor cell niches in embryonic and adult tissues. LRP2 functions are crucial for developmental processes in a number of tissues, including the brain, the eye, and the heart, and defects in this receptor pathway are the cause of devastating congenital diseases in humans. Developmental Dynamics 245:569–579, 2016 . © 2016 Wiley Periodicals, Inc.