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Extracellular matrix bioscaffolds in tissue remodeling and morphogenesis
Author(s) -
Swinehart Ilea T.,
Badylak Stephen F.
Publication year - 2016
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24379
Subject(s) - extracellular matrix , decellularization , microbiology and biotechnology , biology , morphogenesis , regeneration (biology) , progenitor cell , anatomy , stem cell , genetics , gene
During normal morphogenesis the extracellular matrix (ECM) influences cell motility, proliferation, apoptosis, and differentiation. Tissue engineers have attempted to harness the cell signaling potential of ECM to promote the functional reconstruction, if not regeneration, of injured or missing adult tissues that otherwise heal by the formation of scar tissue. ECM bioscaffolds, derived from decellularized tissues, have been used to promote the formation of site appropriate, functional tissues in many clinical applications including skeletal muscle, fibrocartilage, lower urinary tract, and esophageal reconstruction, among others. These scaffolds function by the release or exposure of growth factors and cryptic peptides, modulation of the immune response, and recruitment of progenitor cells. Herein, we describe this process of ECM induced constructive remodeling and examine similarities to normal tissue morphogenesis. Developmental Dynamics 245:351–360, 2016 . © 2015 Wiley Periodicals, Inc.