Premium
Input overload: Contributions of retinoic acid signaling feedback mechanisms to heart development and teratogenesis
Author(s) -
D'Aniello Enrico,
Waxman Joshua S.
Publication year - 2015
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24232
Subject(s) - retinoic acid , biology , signal transduction , microbiology and biotechnology , tretinoin , cell signaling , heart development , embryonic stem cell , genetics , gene
Appropriate levels of retinoic acid (RA) signaling are critical for normal heart development in vertebrates. A fascinating property of RA signaling is the thoroughness by which positive and negative feedback are employed to promote proper embryonic RA levels. In the present short review, we first cover the advancement of hypotheses regarding the impact of RA signaling on cardiac specification. We then discuss our current understanding of RA signaling feedback mechanisms and the implications of recent studies, which have indicated improperly maintained RA signaling feedback can be a contributing factor to developmental malformations. Developmental Dynamics 244:513–523, 2015 . © 2014 Wiley Periodicals, Inc.