Premium
Palatogenesis and cutaneous repair: A two‐headed coin
Author(s) -
Biggs Leah C.,
Goudy Steven L.,
Dunnwald Martine
Publication year - 2015
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24224
Subject(s) - biology , morphogenesis , wound healing , microbiology and biotechnology , wound closure , anatomy , gene , genetics
Background: The reparative mechanism that operates following post‐natal cutaneous injury is a fundamental survival function that requires a well‐orchestrated series of molecular and cellular events. At the end, the body will have closed the hole using processes like cellular proliferation, migration, differentiation and fusion. Results: These processes are similar to those occurring during embryogenesis and tissue morphogenesis. Palatogenesis, the formation of the palate from two independent palatal shelves growing towards each other and fusing, intuitively, shares many similarities with the closure of a cutaneous wound from the two migrating epithelial fronts. Conclusions: In this review, we summarize the current information on cutaneous development, wound healing, palatogenesis and orofacial clefting and propose that orofacial clefting and wound healing are conserved processes that share common pathways and gene regulatory networks. Developmental Dynamics 244:289–310, 2015 . © 2014 Wiley Periodicals, Inc.