Premium
Development of astrocytes in the vertebrate eye
Author(s) -
Tao Chenqi,
Zhang Xin
Publication year - 2014
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24190
Subject(s) - biology , neuroscience , optic nerve , retina , retinal , vertebrate , astrocyte , embryonic stem cell , population , anatomy , central nervous system , genetics , biochemistry , demography , sociology , gene
Astrocytes represent the earliest glial population in the embryonic optic nerve, contributing critically to retinal angiogenesis and formation of brain‐retinal‐barrier. Despite of many developmental and clinical implications of astrocytes, answers to some of the most fundamental questions of this unique type of glial cells remain elusive. This review provides an overview of the current knowledge about the origination, proliferation, and differentiation of astrocytes, their journey from the optic nerve toward the neuroretina, and their involvement in physiological and pathological development of the visual system. Developmental Dynamics 243:1501–1510, 2014 . © 2014 Wiley Periodicals, Inc.