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Embryonic expression of the transforming growth factor beta ligand and receptor genes in chicken
Author(s) -
Cooley James R.,
Yatskievych Tatiana A.,
Antin Parker B.
Publication year - 2014
Publication title -
developmental dynamics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.634
H-Index - 141
eISSN - 1097-0177
pISSN - 1058-8388
DOI - 10.1002/dvdy.24085
Subject(s) - biology , receptor , microbiology and biotechnology , endoglin , somitogenesis , transforming growth factor beta , transforming growth factor , embryonic stem cell , signal transduction , activin receptor , tgf beta signaling pathway , genetics , gene , embryo , embryogenesis , stem cell , somite , cd34
Background: Transforming growth factor‐beta (TGFβ) signaling regulates a myriad of biological processes during embryogenesis, in the adult, and during the manifestation of disease. TGFβ signaling is propagated through one of three TGFβ ligands interacting with Type I and Type II receptors, and Type III co‐receptors. Although TGFβ signaling is regulated partly by the combinatorial expression patterns of TGFβ receptors and ligands, a comprehensive gene expression analysis has not been published. Results: Here we report the embryonic mRNA expression patterns in chicken embryos of the canonical TGFβ ligands ( TGFB1 , TGFB2 , and TGFB3 ) and receptors ( TGFBR1 , TGFBR2 , TGFBR3 ), plus the Activin A receptor, type 1 ( ACVR1 ) and co receptor Endoglin ( ENG ) that also transduce TGFβ signaling. Conclusions: TGFB ligands and receptors show dynamic and frequently overlapping expression patterns in numerous embryonic cell layers and structures. Integrating expression information identifies combinations of ligands and receptors that are involved in specific developmental processes including somitogenesis, cardiogenesis and vasculogenesis. Developmental Dynamics 243:497–508, 2014 . © 2013 Wiley Periodicals, Inc.